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Myomectomy before the clinical observation of mifepristone

Comparability, both past mood, liver and kidney disorders. Observation group, the first 3 months of treatment does not use any other hormone drugs. Second, the Methods: Group 1 from day period of oral mifepristone 12.5mg / d, for 3 months, 2 weeks after stopping surgery before and after treatment in drug investigations were hemoglobin, hematocrit , liver function, and the The control group preoperative routine check and correct anemia after surgery. Detailed records of surgical procedures in both groups, operating time, blood loss, preoperative, intraoperative blood transfusion ratio, preoperative and postoperative 24-hour hemoglobin, hematocrit and so on. Third, the statistical methods: The t test and paired t test) (. Test. Results one of the observation group,[link widoczny dla zalogowanych], check the index before and after treatment (Table 1): Second, the observation group and control group,[link widoczny dla zalogowanych], the comparison operation (see Table 2) : Table 1, taking the observation group before and after comparison of the inspection target (± s) Table 2 Surgical observation group compared to the situation with the control group (± s) on one or the mechanism of mifepristone treatment for uterine fibroids and efficacy Author: 210008 Nanjing University, Affiliated Drum Tower Hospital, hospital studies have shown that many of uterine fibroids is not only a progestin-dependent disease, uterine fibroids and progesterone, or a place of initiation factor -】. mifepristone levels in receptors play a role in anti-progesterone . It is the chemical synthesis of steroidal drugs. has no hormone activity itself, but the body can replace the combination of progesterone and its receptor, blocked the effect of progesterone, the decline in tissue levels of progesterone, uterine fibroids shrink. Yang Young and so on. a report with mifepristone (10mg / d)} sets treatment 3 months, reduce the 43 uterine fibroids with no apparent side effects and amenorrhea. this group of mifepristone (12.5mg / d) 3 months of oral, uterine fibroid volume reduction 41.28 cases of 26 cases of patients with amenorrhea, the effect is obvious. Because the primary role of mifepristone on endometrial progesterone receptors, long-term use causes endometrial thickening, and even individual cases of endometrial lesions reported 1], but the prevalence of women of childbearing age relapse after stopping the shortcomings, and want to keep most of the minor age of women with a uterus, the mean age of 37.6 years, so choose premedication 3 months after withdrawal surgery, only to meet the clinical requirements, but also to avoid long-term side effects of medication. The group of 28 patients before ketone on the surgical treatment of uterine fibroids and other reports of Recnsch. 12.5mg/d3 months of taking mifepristone, uterine artery resistance index significantly increased uterine artery blood flow by up to 4O, is conducive to uterine fibroids volume reduction, and reduces pelvic congestion. This combination of anemia in patients to correct anemia and reduce blood loss before surgery is very effective. uterine fibroid volume reduction that would have a larger diameter of submucosal fibroids after treatment reduced d,[link widoczny dla zalogowanych], N3cm less bureaucratic resectoscope technique possible to avoid laparotomy, shortened operative time uterine resectoscope,[link widoczny dla zalogowanych], resectoscope surgery to avoid water intoxication or other complications. larger fibroids shrink after the muscle wall and ask viable muscle After removing the plastic uterine tumor. As trauma,[link widoczny dla zalogowanych], a small impact on future fertility, but also reduce bleeding. preoperative observation group, no case of intraoperative blood transfusion. by observing the group and the observation group and control group before treatment and after the Check the comparison, we believe that the young, want to keep patients with uterine fibroids, in the full description of the situation, preoperative use of mifepristone 12.5mg / d, treatment for 3 months, the surgery is very beneficial to retain the uterus. worth advocated. The drug has a cheap (oral only three hundred 3 months), the small side (only 3 cases in this group of hot flashes, upset stomach in 1 case), to facilitate oral administration, the current range of clinical applications in obstetrics and gynecology expanding.