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Chief Gray
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 Posted: Sun 20:24, 20 Mar 2011 Post subject: Immune globulin inhibitor treatment of refractory |
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Immune globulin inhibitor treatment of refractory thrombocytopenic purpura Clinical Research
× 10 / L, clinical bleeding symptoms were improved . Section 3d platelet medication about 30 × 10/L22 cases ( 52.3% ), platelets greater than 100x10/L15 drug section 7d (35.7 %), the first 4 weeks of treatment is greater than 100 × 10/L2O platelets (47 .6 %). The average increase in peak platelet (1214-65) X10 / L, the median peak bleeding , asked for the 11d. As the platelet count rising,[link widoczny dla zalogowanych], the case of bleeding symptoms rapidly improved, adverse reactions rare, a small number of patients with neutropenia, fever, peripheral neuritis, no significant liver and kidney dysfunction . JoumalofMedicalForumVo1.29No. 19October2o083 discussions with large doses of immunosuppressive agents in combination with gamma globulin synergy . Use of immunosuppressive drugs slow platelet recovery , the role of persistent , abnormal immune function in the suppression , but also different degrees of inhibition of the normal immune function,[link widoczny dla zalogowanych], have more adverse reactions. Intravenous gamma globulin faster platelet recovery in long-term efficacy is poor,[link widoczny dla zalogowanych], but it increases the normal immune function, both the role of synergistic ,[link widoczny dla zalogowanych], adverse reactions under control. High-dose intravenous gamma globulin may be a closed mononuclear macrophages FC receptor, Sofitel shaped block Fc receptor-mediated macrophage function , so that autoantibody -mediated platelet destruction decreased , while Immune regulation by reducing the synthesis of autoantibodies , inhibition of platelet antibodies and platelet antigen binding and reduce the blood damage the small 77 * plate ,[link widoczny dla zalogowanych], but also increase the bone marrow platelet production, so that the rapid rise in platelets in the short term . Used only for their combination of refractory thrombocytopenic purpura patients or critical condition , with serious bleeding with low platelet or cerebral bleeding tendency of the cases. A
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